Table 3.

Identifying 100 at risk individuals: Impact of targeting high-risk groups for a two-stage screening approach using olfactory testing followed by dopamine transporter imaging. The table shows the number of individuals that would need to be screened based on 4 possible target populations to identify 100 subjects with abnormal imaging. The incidence rates are drawn from the literature for the general population,⁹² 1^st degree relatives of PD patients,⁹³ 1^st degree relatives of known LRRK2 carriers⁴⁷ and patients diagnosed with RBD.¹¹ The primary screen (olfactory testing) is assumed to be 80% sensitive and 90% specific when applied within three years of disease onset.