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Timeline of experimental procedures. Rats are handled daily (home cage control, CTR) or subjected to the chronic unpredictable stress (CUS) procedure for 35 days. Animals are administered saline or riluzole (4 mg/kg) for the 21 last days of the experiment. The efficacy of CUS or riluzole on behavioral performances of the animals in locomotor activity, active avoidance and sucrose preferences test are measured.
