. Author manuscript; available in PMC: 2012 Oct 3.

Published in final edited form as: Nat Genet. 2012 May 6;44(6):651–658. doi: 10.1038/ng.2270

Table 2. Count and frequency of individuals with detectable clonal mosaic events for cancer-free individuals and by first diagnosed cancer site.

Non-hematological cancers are listed by first cancer site and exclude anyone diagnosed with a hematological cancer, shown separately.

	Mosaic Counts			Non-Mosaic Counts			Mosaic Frequency (%)
Site of first cancer	Likely Untreated	Possibly Treated	Total	Likely Untreated	Possibly Treated	Total	Likely Untreated	Possibly Treated	Overall
overall ^*			498			57,201			0.86
cancer-free			194			25,942			0.74
First non-hematologic cancer	185	119	304	13,865	17,394	31,259	1.32	0.68	0.96
bladder	37	6	43	2,240	973	3,213	1.62	0.61	1.32
breast	4	8	12	1,060	1,753	2,813	0.38	0.45	0.42
endometrium	3	6	9	247	624	871	1.20	0.95	1.02
esophagus	1	6	7	53	1,855	1,908	1.85	0.32	0.37
glioma	7	2	9	1,279	441	1,720	0.54	0.45	0.52
kidney	21	3	24	1,241	325	1,566	1.66	0.91	1.51
lung	73	26	99	4,647	2,605	7,252	1.55	0.99	1.35
osteosarcoma	0	3	3	0	760	760		0.39	0.39
ovary	1	3	4	260	283	543	0.38	1.05	0.73
pancreas	2	29	31	379	3,513	3,892	0.52	0.82	0.79
prostate	32	11	43	2,116	1,410	3,526	1.49	0.77	1.20
stomach	2	13	15	99	2,194	2,293	1.98	0.59	0.65
testis	2	0	2	144	503	647	1.37	0.00	0.31
other sites	0	3	3	100	155	255	0.00	1.90	1.16

Any hematologic cancer	8	11	19	34	62	96	19.05	15.07	16.52
leukemia	8	9	17	34	11	45	19.05	45.00	27.42
lymphoid	4	5	9	14	5	19	22.22	50.00	32.14
myeloid	4	3	7	16	5	21	20.00	37.50	25.00
other/nos	0	1	1	4	1	5	0.00	50.00	16.67
lymphoma	0	2	2	0	42	42		4.55	4.55
multiple myeloma	0	0	0	0	9	9		0.00	0.00

overall total of cancer-free individuals and those with non-hematologic cancers