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. Author manuscript; available in PMC: 2012 Sep 30.
Published in final edited form as: Cell. 2011 Sep 30;147(1):235–246. doi: 10.1016/j.cell.2011.08.040

Figure 7. Risperidone rescues hyperactivity and repetitive behavior/perseveration in Cntnap2−/− mice.

Figure 7

(A-B) Open field test. Distance travelled (A) and velocity (B) for vehicle (PBS) and drug treated WT and KO mice (20 min) (C) Nesting behavior. Risperidone improves the nesting score of Cntnap2−/− mice (D) Hot plate. Risperidone did not have an effect in the hyper-reactivity to thermal stimuli (E) Grooming behavior is reduced in risperidone treated mutant mice (10 min) (F) Risperidone improved spontaneous alternation of mutant mice (G) Drug treatment did not have an effect in the three-chamber social interaction test. n=10 mice/genotype and treatment condition. Data are presented as mean ± S.E.M. *p<0.05, **p<0.01, ***p<0.001.