Table 3. EC50s of insulin, IGF1, glargine and glargine metabolites towards IR homodimers and IR/IGF1R hybrids.
| IRA/IRA | IRB/IRB | IRA/IGF1R | IRB/IGF1R | |
| EC50 (nM) | EC50 (nM) | EC50 (nM) | EC50 (nM) | |
| Insulin | 2.15±0.40 | 3.68±1.13 | 84.30±22.74 | 48.15±13.72 |
| Glargine | 2.04±0.50 | 3,88±1.25 | 10.19±1.29 ** | 6.28±1.37 ** |
| M1 | 16.69±3.16 ** | 9.64±2.18 | 225.40±47.69 | 147.08±35.25 |
| M2 | 13.81±2.47 ** | 6.31±0.98 | 314.60±71.85 * | 169.20±18.87 * |
| IGF1 | 50.63±13.45 ** | 130.04±60,95 ** | 4.23±0.82 ** | 3.05±1.10 ** |
Results are the means ± S.E.M. of 4 to 6 independent experiments.
*, **
, p<0.05 or p<0.01 respectively, when compared to insulin.