Table 4.
Diagnostic features of the direct and calculated markers of the βAPB.
| Marker | Cutoff (pg/mL) | Sensitivity (>85%) | Specificity (>80%) | ROC (>0.80) | |
|---|---|---|---|---|---|
| UP Aβ1-40 | 23.2 AD | AD/HC | 40.0 | 93.8 | 0.59 |
| 17.0 MCI | MCI/HC | 85.7 | 68.8 | 0.80 | |
| 22.5 AD | AD/MCI | 40.0 | 71.4 | 0.35 | |
|
| |||||
| DP Aβ1-40 | 63.8 AD | AD/HC | 46.7 | 81.3 | 0.59 |
| 63.8 MCI | MCI/HC | 85.7 | 81.3 | 0.81 | |
| 72.2 AD | AD/MCI | 40.0 | 71.4 | 0.36 | |
|
| |||||
| CB Aβ1-40 | 71.9 AD | AD/HC | 53.3 | 87.5 | 0.65 |
| 71.1 MCI | MCI/HC | 85.7 | 81.3 | 0.85 | |
| 211.3 AD | AD/MCI | 13.3 | 100.0 | 0.40 | |
|
| |||||
| UP Aβ1-42 | 10.28 AD | AD/HC | 46.7 | 87.5 | 0.65 |
| 9.2 MCI | MCI/HC | 85.7 | 81.3 | 0.90 | |
| 67.4 AD | AD/MCI | 6.7 | 100.0 | 0.26 | |
|
| |||||
| DP Aβ1-42 | 47.4 AD | AD/HC | 46.7 | 87.5 | 0.62 |
| 50.3 MCI | MCI/HC | 57.1 | 93.8 | 0.79 | |
| 151.7 AD | AD/MCI | 6.7 | 100.0 | 0.35 | |
|
| |||||
| CB Aβ1-42 | 76.9 AD | AD/HC | 40.0 | 100.0 | 0.74 |
| 59.8 MCI | MCI/HC | 100.0 | 50.0 | 0.72 | |
| 71.3 AD | AD/MCI | 53.3 | 71.4 | 0.48 | |
|
| |||||
| T40 (DP + CB) | 132.7 AD | AD/HC | 53.3 | 81.3 | 0.60 |
| 132.7 MCI | MCI/HC | 85.7 | 81.3 | 0.83 | |
| 550.8 AD | AD/MCI | 13.3 | 100 | 0.37 | |
|
| |||||
| T42 (DP + CB) | 115.8 AD | AD/HC | 53.3 | 87.5 | 0.71 |
| 103.3 MCI | MCI/HC | 100 | 50 | 0.77 | |
| 113.7 AD | AD/MCI | 53.3 | 57.1 | 0.41 | |
|
| |||||
| T-βAPB (T40 + T42) | 235.5 AD | AD/HC | 53.3 | 81.3 | 0.65 |
| 235.5 MCI | MCI/HC | 85.7 | 81.3 | 0.84 | |
| 778.1 AD | AD/MCI | 13.3 | 100 | 0.38 | |
Highlighted in bold are the results that met the criterion considered suitable as figure in the heading. PPV: positive predictive value. NPV: negative predictive value. ROC: area under the receiver operating characteristic curve.