. Author manuscript; available in PMC: 2013 Feb 3.

Published in final edited form as: Cell. 2012 Feb 3;148(3):399–408. doi: 10.1016/j.cell.2012.01.021

Table 1.

Drugs that Inhibit HIF-1

Process Inhibited	Drug Class	Prototype
HIF-1 α protein synthesis	Cardiac glycoside mTOR inhibitor Microtubule targeting agent Topoisomerase I inhibitor	Digoxin Rapamycin 2-Methoxyestradiol Topotecan
HIF-1 α protein stability	HDAC inhibitor HSP90 inhibitor Calcineurin inhibitor Guanylate cyclase activator	LAQ824 17-AAG Cyclosporine YC-1
Heterodimerization	Antimicrobial agent	Acriflavine
DNA binding	Anthracycline Quinoxaline antibiotic	Doxorubicin Echinomycin
Transactivation	Proteasome inhibitor Antifungal agent	Bortezomib Amphotericin B
Signal transduction	BCR-ABL inhibitor Cyclooxygenase inhibitor EGFR inhibitor HER2 inhibitor	Imatinib Ibuprofen Erlotinib, Gefitinib Trastuzumab