Fig. 5.
Whole-brain amygdala task-based functional connectivity (tb-fcMRI) maps are shown using Z statistics and visualized using the population-average, landmark- and surface-based (PALS) atlas.110 (A) Following negative distraction for both controls (top panel) and patients (bottom panel); (B) Following neutral distraction for both controls (top panel) and patients (bottom panel); (C) Results of an independent samples t-test comparing patients vs controls following negative distraction; (D) Results of a Diagnosis × Distracter Condition interaction (ie, foci where controls show increases in negative coupling between amygdala-PFC as a function of emotion and patients do not). In panels (C) and (D), we show foci using a Z > 2.5 threshold demonstrating that, even with a lower statistical significance threshold, group differences in amygdala tb-fcMRI are centered mainly on the prefrontal cortex and not elsewhere. Brighter colors mark regions showing either more positive or more negative tb-fcMRI with amygdala. The online version of this article shows positive and negative tb-fcMRI with the amygdala in orange–yellow and blue colors, respectively. The complete list of significant foci at appropriate whole-brain type I error correction (z > 3.00, k = 13, corresponding to P < .05) is shown in table 2.