Table 1.
LPS treatment decreases SCOT catalytic activity
| Rat tissue | Time after LPS injection, h | SCOT catalytic activity, nmol per min per mg |
|---|---|---|
| Kidney | 0 | 79.8 ± 2.4 (4) |
| 6 | 63.5 ± 4.8* (4) | |
| 9 | 65.0 ± 5.6 (4) | |
| 16 | 76.0 ± 5.4 (5) | |
| 24 | 76.7 ± 0.8 (3) | |
| Heart | 0 | 105.3 ± 6.8 (3) |
| 6 | 84.7 ± 5.3* (3) | |
| Brain | 0 | 22.4 ± 0.3 (3) |
| 6 | 25.6 ± 1.2 (3) |
The forward direction of the SCOT catalytic reaction was measured. Catalytic activity was expressed as nmol of acetoacetyl-CoA formed per min per mg of total protein. Data represent mean ± SEM. Number of animals used is shown in parentheses.
*
, P < 0.05.