Table 1.
Curcumin table.
| Name | Description | % Curcumin in chow | Curcumin intake (mg/kg day)a | Plasma curcumin concentration (μM) | Survival (days) |
|---|---|---|---|---|---|
| Chromadex | 99% pure curcumin from turmeric powder mixed at 20,000 ppm with NIH 7013 base chow | 2% | 3500 | <0.1b,f | 84.3±2.0** |
| Acros | 85% pure curcumin from turmeric powder mixed at 2000 ppm with 5P14 base chowe. Harlan Teklad TD.09288. | 0.17% | 298 | 0.305±0.164c | 83.8±3.8 |
| NIH 7013 | Modified 6% mouse/rat sterilizable diet | 0% | 0 | NDd | 72.6±2.6 |
| Lipidated Curcumin Verdure Sciences | Lot 024908G2711CLEG 0.25% proprietary mixture of curcumin with stearic acid and phosphatidyl choline mixed with NIH 7013 base chow | 0.05% | 88 | 0.044±0.017c | 77.6±1.4 |
| Lipidated vehicle | Proprietary mixture of stearic acid and phosphatidyl choline (Verdure Sciences) made in 5P14 base chowe. Harlan Teklad TD.09288 | 0% | 0 | 0c | 86.2±1.9** |
**
p<0.01 against NIH 7013.
a
Curcumin intake was calculated using weights of 20 g per mouse, which for Npc1−/− mice is their peak weight.
b
Laboratory 1.
c
Laboratory 2.
d
Not determined.
e
5P14 similar to 7013 except has slightly higher protein and less fat than NIH 7013.
f
No blood from group. Separate group of animals fed same dose. Subtle differences in curcumin chow preparation may have affected absorption.