Table 2. Somatic mutations that alter miRNA targeting in linkage disequilibrium blocks of association study markers.
Somatic mutation | Cancer type | Gene | miRNA | Germline mutation in target sitea | Association study markera | LD block boundaries | Cancer type in association study | P-Value |
Chr4:g.96075969G>T | Lung | BMPR1B | miR-125b | rs1434536 (4) | rs11097457 (844) | 96061509–96091524 | Breast Neoplasms [46] | 1.97E-04 |
Chr19:g.51363764A>C | Prostate | KLK3 | miR-138, miR-210, hsa-miR-675-5p | rs1803136 (1) | rs2735839 (859) | 51361757–5134623 | Prostatic Neoplasms [49] | 2.00E-18 |
Chr5:g.141691500G>T | Prostate | SPRY4 | miR-608 | rs72117814 (1) | rs4624820 (9712) | 141664185–141693593 | Testicular Neoplasms [53] | 3.00E-13 |
: The number in parentheses below the name of the polymorphism is the distance, in bp, from the germline mutation to the somatic mutation.