Figure 3.
Dominant indicator phylotypes of health state and genotype. Dominant indicator phylotypes are presented with their relative abundance (as percent) in each sample of DNA- and RNA-based sequencing libraries. Each phylotype is annotated with the closest reference sequence from the Living Tree Project (Yarza et al., 2008), and information is in bold font when they share at least 97% sequence similarity. Dominant indicators are significantly associated with a specific condition and show >0.5% difference in relative abundance between two conditions (for details see Materials and Methods). The phylotypes are grouped and color coded according to the condition for which they are an indicator for each combination of treatment and genotype. Each column in the ‘DNA template' and ‘RNA template' blocks represents a sample from a single mouse. A representative sequence for each indicator phylotype is given in the supplement. Detailed information on sample numbers and sequencing depth is available in Supplementary Figure S3.