. Author manuscript; available in PMC: 2012 Oct 22.

Published in final edited form as: Nat Biotechnol. 2008 Aug;26(8):901–908. doi: 10.1038/nbt.1484

Table 2.

Genetic mutations and development of inhibitors in hemophilia

Disease	Type of mutation	Inhibitor rate	Anaphylaxis rate
Hemophilia A^4,5	Large deletion	88%	Rare
	Moderate deletion	25–41%
	Minor deletion	16–21%
	Intron 22 inversion	20%
	Missense	5%
Hemophilia B^8,88	All mutations	5%	<2%
	Large deletion or minor deletion with stop	50–100% (3/6 or 6/6 patients)	26%