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. 2012 Jul 5;4(9):882–895. doi: 10.1002/emmm.201201228

Figure 1. Increased bile secretion following silencing of miR-33.

Figure 1

  1. Bile recovered from the gallbladder of mice (n = 5) on chow diet, injected with saline, and scrambled or anti-miR-33 oligonucleotides (5 mpk i.v., for 2 consecutive days). Animals were then kept for a week on chow and fasted overnight before sample collection.
  2. Levels of phosphatidylcholine (PC), cholesterol (chol) and bile acids present in gallbladder bile in the same mice.
  3. Relative expression of hepatic canalicular transporters in the same mice.
  4. A different group of mice (n = 6–8) was injected as described above. A week later, mice were anesthetized, the bile duct cannulated, and hepatic bile collected for 1 h.
  5. Levels of bile acids, phosphatidylcholine (PC), cholesterol (chol) present in bile from the last group of mice. Data shown as mean ± SEM. *p < 0.05; **p < 0.01.