Table 1.
Population-based studies of maternal body mass index (BMI) and schizophrenia in adult offspring
| Study | Design and setting | Case/control | Outcome and diagnostic criteria | Case identification | Age at follow-up (years) | Source of maternal BMI data |
|---|---|---|---|---|---|---|
| Jones et al. (1998) (36) | PC, Finnish 1966 birth cohort | 76/10,502 | Schizophrenia (DSM III R) | Hospital in- and out-patient attendance records | 28 | Records from midwife home visits and prenatal clinics |
| Schaefer et al. (2000) (39) | PC, subsample of CHDS cohort, United States | 63/6,570 | Schizophrenia and spectrum disorders (SSD) (DIGS)* | Hospital records, case-note review, and interview | 30–38 | Medical records and antenatal clinic records |
| Wahlbeck et al. (2001) (38) | RC, Helsinki, Finland | 114/7,086 | Schizophrenia, schizophreniform and schizoaffective (ICD or DSM) | Hospital discharge records | 63–72 | From birth records |
| Kawai et al. (2004) (42) | Case- control, Hamamatsu City, Japan | 52/284 | Schizophrenia (DSM IV) | Hospital in- and out-patient records | 19 | Mother and child handbook completed during pregnancy |
*
SSD includes schizophrenia, schizoaffective disorder, other non-affective psychosis and schizotypal personality disorder.
CHDS, child health and development study; DIGS, Diagnostic Interview for Genetic Studies; PC, prospective cohort study; RC, retrospective cohort study.