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The tricarboxylic-acid cycle during (a) typical metabolism and (b) with high levels of propionic acid. Propionic acid is metabolized to propionyl-CoA, which inhibits the proximal portion of the tricarboxylic-acid cycle and enhances the distal portion of the tricarboxylic-acid cycle (see discussion for details). FADH2, flavin adenine dinucleotide; NADH, nicotinamide adenine dinucleotide.
