Figure 5. Empirical Cumulative Distribution Function of the NC statistic for alleles at minor allele count 3 in GoNL data.
Synonymous derived variants serve as the baseline distribution. The distribution of NC for probably damaging derived missense variants is notably shifted towards higher values, consistent with their younger age. The NC-statistic distribution for ancestral alleles are at minor allele count 3 is strongly shifted towards lower values, consistent with much older age of those alleles.