Table 3.
LMW serum proteins with a different spectral count in three same subject samples before versus after cognitive decline. Qualifications: 1. Proteins were identified by at least four spectra within a single disease group, 2. Proteins demonstrated ≥ 100% difference in spectral count between before and after cognitive decline, 3. The direction of change in spectral count was the same in at least two subjects and could not be counter directional in the third subject. Percent difference was calculated as difference between before and after cognitive decline samples divided by average of before and after cognitive decline samples. Proteins in bold were exclusively found either before or after cognitive decline
| Regulation | Accession | Protein name | Spectra |
% difference after/before cognitive decline | |||||
|---|---|---|---|---|---|---|---|---|---|
| before Sample A | cognitive Sample B | decline Sample C | after Sample A | cognitive Sample B | decline Sample C | ||||
| ↑ | P78547 | Prosaposin | 0 | 0 | 0 | 1 | 2 | 1 | 200% |
| ↑ | P08493 | Matrix gla protein | 0 | 0 | 0 | 3 | 0 | 1 | 200% |
| ↑ | Q32LZ2 | Biliverdin reductase B | 0 | 0 | 0 | 1 | 0 | 3 | 200% |
| ↑ | Q86UQ9 | Citron | 0 | 0 | 0 | 2 | 2 | 0 | 200% |
| ↑ | 095740 | Serine (or cysteine) proteinase inhibitor, clade B, member 4 | 0 | 0 | 0 | 1 | 0 | 3 | 200% |
| ↑ | Q6EZF6 | Predicted: similar to neutrophil defensin 1 precursor | 0 | 2 | 1 | 0 | 4 | 18 | 152% |
| ↑ | P31151 | S100 calcium-binding protein A7 | 0 | 1 | 0 | 1 | 1 | 4 | 143% |
| ↑ | Q59EA4 | Phospholipase D1, phophatidylcholine-specific | 0 | 0 | 1 | 2 | 1 | 2 | 133% |
| ↑ | Q16782 | Serum amyloid A2 | 0 | 0 | 1 | 1 | 1 | 2 | 120% |
| ↓ | O00109 | Keratin 9 | 6 | 1 | 7 | 0 | 0 | 0 | 200% |
| ↓ | Q9P190 | Inter-alpha (globulin) inhibitor H4 | 2 | 4 | 4 | 0 | 0 | 0 | 200% |
| ↓ | Q02985 | Complement factor h isoform a precursor | 4 | 2 | 4 | 1 | 0 | 0 | 164% |
| ↓ | Q2KHQ6 | Apolipoprotein 11 isoform a precursor | 3 | 3 | 1 | 0 | 1 | 0 | 150% |
| ↓ | Q6GSJ0 | Keratin 1 | 36 | 5 | 7 | 3 | 4 | 3 | 131% |
| ↓ | 043608 | Roundabout, axon guidance receptor, homolog 2 | 2 | 2 | 0 | 0 | 1 | 0 | 120% |
| ↓ | Q9UGQ0 | Rsb-66 protein | 2 | 0 | 2 | 0 | 0 | 1 | 120% |
| ↓ | Q5SRP4 | Apolipoprotein m | 4 | 4 | 2 | 2 | 1 | 0 | 108% |
| ↓ | Q7L5M9 | Keratin 10 | 8 | 7 | 11 | 2 | 3 | 3 | 106% |