Figure 2. Factors regulating the IL2 (A), IL2RA (B), IL2RB (C), and IL2RG (D) genes.
For each gene, the binding locations of transcription factors are shown. For some of these factors, there are only in vitro data that indicate their importance, whereas for others such as STAT5A and STAT5B, extensive in vivo data have established their importance (e.g., of STAT5A and STAT5B for regulation of IL-2Rα expression). (A) Multiple factors, including for example NFAT, AP1, and NF-κB bind to and regulate the IL2 gene. (B) In the IL2RA gene, PRRI binds SP1, SRF, and NF-κB; PRRII binds Elf-1 as well as HMG-I and/or HMG-Y; PRRIII binds STAT5A, STAT5B, ELF1, and GABP, as well as HMG-I and/or HMG-Y, PRRIV binds NFAT, AP1, STAT5A, and STAT5B; PRRV binds SMAD3, AP1, and CREB-ATF factors, and PRRVI binds AP1 and CREB-ATF factors. (C) Factors including ETS1 bind to and regulate the IL2B gene. (D) Only limited information is available regarding the factors regulating IL2RG.