Table 1.
Power of VC-score tests under different sample sizes
|
Design |
h2 |
Significance level (α) |
||
|---|---|---|---|---|
| 0.05 | 1 × 10-5 | 1 × 10-6 | ||
| I. 500/3000 |
|
|
|
|
| |
0.01 |
0.840 |
0.355 |
0.270 |
| |
0.02 |
1 |
0.855 |
0.780 |
| |
0.03 |
1 |
0.985 |
0.980 |
| II. 750/2000 |
|
|
|
|
| |
0.01 |
0.890 |
0.345 |
0.235 |
| |
0.02 |
1 |
0.825 |
0.725 |
| |
0.03 |
1 |
0.975 |
0.970 |
| III. 750a/2000 |
|
|
|
|
| |
0.01 |
0.94 |
0.435 |
0.335 |
| |
0.02 |
1 |
0.92 |
0.880 |
| 0.03 | 1 | 1 | 0.990 | |
Note.—The design column indicates # of families / # of unrelated individuals. Only nuclear families are simulated, with each family having two parents with a mean of two children.
a. 750 families simulated with enriched risk haplotypes.