Table 2.
Comparison of Neuropathologic Lesions Among 3 Subgroups of Dementia Associated With Patients With Parkinson Disease
| Characteristic | Synuclein Only (n = 12) | Synuclein Plus Aβ (n = 19) | Synuclein Plus Aβ Plus Tau (n=1) |
|---|---|---|---|
| Braak Lewy body stage for synucleinopathy, mode, (range). | 6 (5–6) | 6 (5–6) | 6 |
| Braak amyloid stage for Aβ deposition, mode (range) | 0 (0–1) | 3 (2–3) | 3 |
| Braak NFT stage for tauopathy, mode (range) | 1 (1–4) | 3 (1–4) | 6 |
| Neuropathologic diagnostic criteria, % of patientsa | |||
| Khachaturianb | 0 | 94.7 | 100 |
| CERADc | 0 | 15.8 | 100 |
| NIA-Reagand | 0 | 0 | 100 |
Abbreviations: CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; NFT, neurofibrillary tangle; NIA, National Institute on Aging.
Additional pathologic changes: 4 patients had TDP-43 inclusions in the medial temporal lobe,27,31 1 patient had argyrophilic grain disease,27 1 patient had a lacunar infarct in the hippocampus, and 1 patient had a lacunar infarct in the thalamus.
Percentage of patients who met Khachaturian criteria for Alzheimer disease.
Percentage of patients who met criteria for probable or definite Alzheimer disease by CERAD criteria.
Percentage of patients who met the NIA-Reagan criteria for a high likelihood that the dementia syndrome is due to Alzheimer disease; in the combined Alzheimer disease and dementia with Lewy bodies criteria of McKeith et al,8 there is a low/intermediate likelihood that the Alzheimer disease causes dementia.