Table 3.
Comparison of combined outcomes (adenocarcinomas of the esophagus or gastric cardia or high-grade dysplasia) among Barrett’s esophagus patients with columnar lined epithelium of the esophagus (CLE) with or without specialized intestinal metaplasia (SIM)
| Characteristic | CLE without SIM, incidence: % per year (95% Confidence Interval [CI]) | CLE with SIM, incidence: % per year (95% CI) | Hazard ratio (95% CI) | P* |
| Sex | ||||
| Female | 0.05 (0.02 to 0.11) | 0.26 (0.18 to 0.38) | 5.65 (2.18 to 14.68) | <.001 |
| Male | 0.10 (0.06 to 0.17) | 0.45 (0.36 to 0.56) | 4.63 (2.52 to 8.49) | <.001 |
| Age category, y | ||||
| <50 | 0.03 (0.01 to 0.10) | 0.25 (0.15 to 0.41) | 7.02 (2.05 to 24.09) | .001 |
| 50–59 | 0.10 (0.04 to 0.23) | 0.37 (0.25 to 0.54) | 3.78 (1.45 to 9.87) | .002 |
| 60–69 | 0.11 (0.05 to 0.26) | 0.49 (0.35 to 0.68) | 4.46 (1.75 to 11.35) | .001 |
| 70–79 | 0.08 (0.03 to 0.23) | 0.43 (0.29 to 0.64) | 5.45 (1.64 to 18.09) | .001 |
| ≥80 | 0.08 (0.01 to 0.44) | 0.29 (0.13 to 0.63) | 3.39 (0.41 to 28.25) | .135 |
| Visible segment seen | ||||
| Unknown | 0.07 (0.04 to 0.12) | 0.41(0.32 to 0.52) | 6.27 (3.31 to 11.87) | <.001 |
| Yes | 0.09 (0.04 to 0.20) | 0.33 (0.24 to 0.45) | 3.72 (1.58 to 8.77) | .001 |
| Segment length† | ||||
| Short | 0.05 (0.01 to 0.28) | 0.15 (0.05 to 0.44) | 2.92 (0.31 to 28.76) | .47 |
| Long | 0.23 (0.08 to 0.67) | 0.50 (0.34 to 0.74) | 2.19 (0.66 to 7.29) | .36 |
| Unknown | 0.06 (0.03 to 0.10) | 0.37 (0.30 to 0.46) | 5.72 (3.18 to 10.28) | <.01 |
| Index dysplasia status | ||||
| No dysplasia | 0.06 (0.04 to 0.10) | 0.31 (0.25 to 0.38) | 5.04 (2.86 to 8.89) | <.001 |
| Low grade | 0.91 (0.31 to 2.64) | 1.45 (0.98 to 2.13) | 1.53 (0.47 to 5.10) | .75 |
| Unknown | 0 | 0.33 (0.06 to 1.85) | Not calculable | NA |
*
P values were from two-sided tests, using Cox proportional hazards modeling to estimate hazard ratios.
†
Segment length was categorized as short (<3cm), long (>3cm), or unknown.