. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Am J Psychiatry. 2012 Nov 1;169(11):1194–1202. doi: 10.1176/appi.ajp.2012.12020248

TABLE 1.

Assessment of Brain-Derived Neurotrophic Factor (BDNF) Dependency on Target Gene Expression in Bdnf ^+/− and Bdnf ^KIV Mice^a

Gene Code	Gene Name	Bdnf ^+/− Mice						Bdnf ^KIV Mice
		Combined Male-Female		Male		Female		Combined Male-Female		Male		Female
		Average Log Ratio^b	p	Average Log Ratio^b	p	Average Log Ratio^b	p	Average Log Ratio^b	p	Average Log Ratio^b	p	Average Log Ratio^b	p
Bdnf-IX	Brain-derived growth factor	−0.56^†	0.02^†	−0.74^†	0.01^†	−0.34	0.17	−0.70^†	0.02^†	−0.62^†	0.03^†	−0.80^‡	0.001^‡
Trkb (Ntrk2)	Tyrosine kinase receptor	0.03	0.43	−0.01	0.48	0.07	0.34	−0.08	0.24	−0.02	0.45	−0.16	0.07
High BDNF dependency
Cort	Cortistatin	−0.68^‡	0.001^‡	−0.64^‡	0.002^‡	−0.72^†	0.04^†	−1.30^‡	1.9E-04^‡	−0.92^†	0.05^†	−1.82^‡	4.4E-06^‡
Vg f	Neurotrophic growth factor inducible	−0.64^‡	0.001^‡	−0.56^†	0.04^†	−0.74^‡	0.002^‡	−0.24	0.10	−0.53^†	0.02^†	0.15	0.26
Sst	Somatostatin	−0.59^‡	0.003^‡	−0.41^†	0.01^†	−0.80^†	0.004^†	−0.60^‡	1.4E-04^‡	−0.64^‡	0.003^‡	−0.55^†	0.01^†
Tac1	Protachykinin-1	−0.73^‡	5.1E-05^‡	−0.66^‡	0.002^‡	−0.81^‡	0.001^‡	−0.82^‡	<0.001^‡	−0.70^†	0.03^†	−1.00^‡	4.7E-05^‡
Npy	Neuropeptide Y	−0.55^†	0.01^†	−0.45^†	0.05^†	−0.68^†	0.05^†	−0.42^‡	0.001^‡	−0.47^†	0.01^†	−0.34^†	0.03^†
Intermediate BDNF dependency
Snap25	Synaptosomal-associated protein 25	−0.37^†	0.04^†	−0.44^†	0.04^†	−0.29	0.20	0.02	0.44	−0.27	0.11	0.43^‡	0.004^‡
Gad2 (Gad65)	Glutamate decarboxylase 2	−0.33^†	0.04^†	−0.54^†	0.02^†	−0.08	0.32	−0.02	0.46	−0.10	0.33	0.10	0.12
Low or no BDNF dependency
Gad1 (Gad67)	Glutamate decarboxylase 1	−0.09	0.30	−0.33^†	0.03^†	0.19	0.25	0.03	0.39	−0.16	0.12	0.29^†	0.05^†
Pvalb	Parvalbumin	0.03	0.44	−0.35	0.1	0.47	0.07	−0.09	0.22	−0.19	0.16	0.04	0.39
Rgs4	Regulator of G protein signaling 4	−0.13	0.36	−0.33^†	0.04^†	0.11	0.45	−0.05	0.32	0.04	0.41	−0.18	0.14
Slc6a1	GABA transporter 1	−0.31	0.10	−0.42	0.03	−0.17	0.35	0.10	0.28	−0.10	0.35	0.39^†	0.02^†
Calb2	Calretinin	0.32	0.32	−0.48	0.10	1.25	0.15	0.20	0.18	0.29	0.20	0.09	0.32
Gabra1	GABA-A receptor, alpha 1	0.13	0.16	0.05	0.40	0.23	0.1	0.00	0.5	0.09	0.23	−0.12	0.22

Mice heterozygous for a constitutive deletion of the Bdnf gene are identified as Bdnf ^+/− (N=13 [seven were male, and six were female]; comparison mice: N=13 [seven were male, and six were female]), and mice with a targeted disruption of exon IV are identified as Bdnf^KIV (N=12 [seven were male, and five were female]; comparison mice: N=12 [seven were male, and five were female]).

Data indicate average log ratio of the experimental group relative to the comparison group.

^†

Significant at p<0.05.

^‡

Significant after correction for multiple testing.