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. Author manuscript; available in PMC: 2014 Apr 2.
Published in final edited form as: Cell Metab. 2013 Apr 2;17(4):549–561. doi: 10.1016/j.cmet.2013.03.009

Figure 1. ABCA1 and ABCG1 expression is altered in senescent macrophages.

Figure 1

Quantitative mRNA analysis of ABCA1 and ABCG1 in splenic (A), peritoneal (B) macrophages and PBMCs (C) isolated from 3, 12 or 18 months old mice. (D) CNV was induced in 3 or 18 months old mice and eye macrophages harvested by laser microdissection were analyzed for ABCA1 and ABCG1 expression by qPCR. (E) Whole cell lysate of peritoneal macrophages of 3 or 18 months old mice were subjected to immunoblot analysis with antibodies against ABCA1, ABCG1 or β-Actin. (F) Relative flow cytometry profiles of ABCA1 and ABCG1 in peritoneal macrophages isolated from 3 or 18 months old mice. Iso = negative isotype control. Values are expressed as mean + SE (A–D). Statistically significant difference *P<0.05, **P<0.01, ***P<0.001.