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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Steroids. 2013 Feb 1;78(6):538–541. doi: 10.1016/j.steroids.2013.01.005

Figure 2. ERβ activity at the E-cadherin promoter in PCa cells.

Figure 2

(A) In a redox neutral milieu, ligand binds ERβ and initiates receptor dimerization, occupancy of its cognate DNA-binding element in the E-cadherin promoter, and activation of transcription. (B) In the presence of H2O2, ERβ is oxidized at the 2nd zinc-finger motif and is unable to dimerize, thus destabilizing its DNA-binding capacity and leading to a loss of E-cadherin transcriptional activation.