Table 6. Associations between behavioral measures and molecular analyses.

Associations between behavioral measures and molecules analyses. Correlation coefficients were calculated between central immune gene upregulation, as determined by the first microarray gene expression factor, and peripheral immune gene upregulation, as determined by the first and second cytokine factors, and the behavioral endpoints. We observed that “central immune gene upregulation”, as indexed by PFC immune gene expression, was a better predictor of behavior than “peripheral immune gene upregulation” as indexed by peripheral cytokine levels. Central immune gene upregulation was associated with significant associations with PR performance, average reward obtained on the CSRTT, average responses on the CSRTT, average distance traveled on the open field, average distance from the center of the open field, and the number of interactions with a novel object. All but PR performance survived Bonferonni correction for multiple comparisons. We also observed significant correlations between peripheral and central immune gene upregulation: r=0.495 for central immune gene upregulation and peripheral immune gene upregulation, factor 1, p=0.02; r=0.43, p=0.04 for central immune gene upregulation and peripheral immune gene upregulation, factor 2.