Figure 10.
Loss of dFmr1 gene function increases daytime sleep intensity. A, Synaptic homeostasis hypothesis schema. B, Synaptic downscaling is hypothesized to be engaged by increased sleep intensity. C, Male sleep intensity profiles for up to 20 min of inactivity during the light and dark period based on 1 min bins for a loss of function mutant of the fragile-X mental retardation gene (d50, n = 34, red) compared with its genetic background control (w1118, n = 68, blue). Day: w1118 r2 = 0.91; d50, r2 = 0.96. Night: w1118 r2 = 0.80; d50, r2 = 0.95. D, Deep sleep response probability (RP) and statistics, data from C. *p < 0.05 by Wilcoxon rank-sum test. E, Female sleep intensity profiles for day and night for a loss of function mutant of the Fmr1 gene (d50, n = 34, red graph, compared with its genetic background control (w1118, n = 68, blue graph). Data are normalized means fit by a third-order polynomial (see Materials and Methods). w1118/+, r2 = 0.68; d50, r2 = 0.95. w1118/+, r2 = 0.80; d50, r2 = 0.98. F, Deep sleep RP data and statistics for sleep intensity data in E. *p < 0.05 by Wilcoxon rank-sum test.