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. 2013 Jan 1;2(1):e23820. doi: 10.4161/jkst.23820

Table 1. Regulation of chemokine synthesis by IFN and STATs 1/2.

Cell/animal Stimulus/disease IFN type involved STAT involved Chemokine regulated References
Mouse macrophages
IFN-γ or IFN-γ/TNF
IFN-γ
STAT1
CCL2/MCP1 ↑
37, 45 and 128
CXCL9/MIG ↑
CXCL10/IP10 ↑
CCL12/MCP5 ↑
IFN-γ/PamCys
IFN-γ
nd
CCL2/MCP1 ↑
52
LPS
nd
STAT1
CXCL10/IP10 ↑
45 and 129
CCL12/MCP5 ↑
LPS/IFN-γ
IFN-γ
STAT1
CXCL1/KC/GROα ↓
45
CXCL2/MIP2/GROβ ↓
CCL2/MCP1 ↓
CCL4/MIP1β ↓
TNF
IFN-β
STAT1
CCL5/RANTES ↑
11
CXCL9/MIG ↑
CXCL10/IP10 ↑
Listeria monocytogenes
IFN-I
nd
CCL2/MCP1 ↑
42
Mouse splenocytes
IFN-α
IFN-α
STAT1
CCL2/MCP1 ↓
46
CCL5/RANTES ↓
CCL7/MCP3 ↓
Human monocytes
IFN-γ
IFN-γ
STAT1
Inhibition of migration in response to CCL2
130
TNF
IFN-β
STAT1
CCL5/RANTES ↑
11
CXCL9/MIG ↑
CXCL10/IP10 ↑
M1 polarization (IFN-γ/LPS)
IFN-γ
nd
CCL5/RANTES ↑
44 and 131
CCL15/MIP1δ ↑
CCL20/MIP3α ↑
CXCL9/MIG ↑
CXCL10/IP10 ↑
Human monocyte-derived DC
Sendai virus
IFN-I
ISGF3
CCL19/MIP3β ↑
40
Salmonella Typhimurium
Human PBMC
IFN-λ
IFN-λ
nd
CXCL9/MIG ↑
132
CXCL10/IP10 ↑
CXCL11/I-TAC ↑
Mouse primary cortical neurons
IFN-α
IFN-α
STAT1
CXCL10/IP10 ↑
133
Human astrocytes
IFN-γ/IL-1β
IFN-γ
nd
CXCL11/I-TAC ↑
36
IFN-β/IL-1β
IFN-β
ISGF3 (?)
CCL5/RANTES ↑
32
Mouse microglia
IFN-γ
IFN-γ
STAT1
CXCL9/MIG ↑
41
Human plasmacytoid DC (MS patient)
IFN-β/TLR9 ligand
IFN-β
nd
CCL3/MIP1α ↓
48
CCL4/MIP1β ↓
CCL5/RANTES ↓
Human T cells (MS patient)
IFN-β
IFN-β
nd
CCL3/MIP1α ↓
47
CCL5/RANTES ↓
CCR5 ↓
Mouse
MCMV infection
IFN-I
nd
CCL2/MCP1 ↑
49
CCL3/MIP1α ↑
50
CCL7/MCP3 ↑
51
CCL12 ↑
 
Mouse liver
MCMV infection
IFN-γ
nd
CXCL9/MIG ↑
49
Mouse brain
LCMV infection
IFN-γ
nd
CCL2/MCP1 ↑
55
CCL3/MIP1α ↑
CCL5/RANTES ↑
CXCL10/IP10 ↑
Mouse cornea
HSV-1
IFN-α
nd
CCL2/MCP1 ↑
34
Mouse
Vaccinia virus
IFN-I, IFN-γ
nd
CXCL9/MIG ↑
134
West Nile virus
IFN-I
nd
CCL2/MCP1 ↑
135
CCL5/RANTES ↑
CXCL10/IP10 ↑
Influenza virus
IFN-I
nd
CXCL1/KC ↓
23
Streptococcus pneumoniae
CXCL2/MIP2 ↓
Mouse peritoneal cavity
Listeria monocytogenes
IFN-I
nd
CCL2/MCP1 ↑
42
nd
STAT1 (macrophages)
CCL3/MIP1α ↓
26
STAT1 (DC)
CCL2/MCP1 ↑
CCL5/RANTES ↑
STAT1 (T cells)
CCL2/MCP1 ↑
CCL5/RANTES ↑
Mouse
Francisella tularensis
IFN-γ
nd
CCL2/MCP1 ↑
52
Polymicrobial peritonitis (CASP)
IFN-I
nd
CCL2 ↓
78
Polymicrobial peritonitis (CLP)
IFN-I
nd
CXCL10 ↑
53
Trypanosoma cruzi
IFN-γ
nd
CXCL9/MIG ↑
136
CXCL10/IP10 ↑
Paracoccidioides brasiliensis
IFN-γ
nd
CCL5/RANTES ↑
137
CXCL1/KC/GROα ↓
CCL3/MIP1α ↓
Candida albicans
IFN-I
nd
CCL2/MCP1 ↑
71
CXCL1/KC/GROα ↑
Mouse thyroid gland
IFN-γ transgene (thyroid gland)
IFN-γ
nd
CXCL9/MIG ↑
56
CXCL10/IP10 ↑
CCL4/MIP1β ↑
CCL5/RANTES ↑
CXCL11/I-TAC ↑
Mouse mast cells
Imiquimod
IFN-I
nd
CCL2/MCP1 ↑
59
Mouse
TNF
IFN-I
nd
CXCL9/MIG ↑
27
CXCL10/IP10 ↑
CXCL11/I-TAC ↑
Allergic asthma
IFN-γ
STAT1
CXCL9/MIG ↑
58
CXCL10/IP10 ↑
ConA-induced hepatitis
IFN-γ
STAT1
CXCL5/ENA-78 ↑
138
CXCL9/MIG ↑
CXCL10/IP10 ↑
CXCL11/I-TAC ↑
Mouse (astrocytes)
EAE
IFN-γ
nd
CXCL10/IP10 ↑
57
Human (MS patient) IFN-β IFN-β nd CCL2/MCP1 ↑
139
CXCL10/IP10 ↑

nd, not determined