Table 1. Regulation of chemokine synthesis by IFN and STATs 1/2.
Cell/animal | Stimulus/disease | IFN type involved | STAT involved | Chemokine regulated | References |
---|---|---|---|---|---|
Mouse macrophages |
IFN-γ or IFN-γ/TNF |
IFN-γ |
STAT1 |
CCL2/MCP1 ↑ |
37, 45 and 128 |
CXCL9/MIG ↑ | |||||
CXCL10/IP10 ↑ | |||||
CCL12/MCP5 ↑ | |||||
IFN-γ/PamCys |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
52 |
|
LPS |
nd |
STAT1 |
CXCL10/IP10 ↑ |
45 and 129 |
|
CCL12/MCP5 ↑ | |||||
LPS/IFN-γ |
IFN-γ |
STAT1 |
CXCL1/KC/GROα ↓ |
45 |
|
CXCL2/MIP2/GROβ ↓ | |||||
CCL2/MCP1 ↓ | |||||
CCL4/MIP1β ↓ | |||||
TNF |
IFN-β |
STAT1 |
CCL5/RANTES ↑ |
11 |
|
CXCL9/MIG ↑ | |||||
CXCL10/IP10 ↑ | |||||
Listeria monocytogenes |
IFN-I |
nd |
CCL2/MCP1 ↑ |
42 |
|
Mouse splenocytes |
IFN-α |
IFN-α |
STAT1 |
CCL2/MCP1 ↓ |
46 |
CCL5/RANTES ↓ | |||||
CCL7/MCP3 ↓ | |||||
Human monocytes |
IFN-γ |
IFN-γ |
STAT1 |
Inhibition of migration in response to CCL2 |
130 |
TNF |
IFN-β |
STAT1 |
CCL5/RANTES ↑ |
11 |
|
CXCL9/MIG ↑ | |||||
CXCL10/IP10 ↑ | |||||
M1 polarization (IFN-γ/LPS) |
IFN-γ |
nd |
CCL5/RANTES ↑ |
44 and 131 |
|
CCL15/MIP1δ ↑ | |||||
CCL20/MIP3α ↑ | |||||
CXCL9/MIG ↑ | |||||
CXCL10/IP10 ↑ | |||||
Human monocyte-derived DC |
Sendai virus |
IFN-I |
ISGF3 |
CCL19/MIP3β ↑ |
40 |
Salmonella Typhimurium | |||||
Human PBMC |
IFN-λ |
IFN-λ |
nd |
CXCL9/MIG ↑ |
132 |
CXCL10/IP10 ↑ | |||||
CXCL11/I-TAC ↑ | |||||
Mouse primary cortical neurons |
IFN-α |
IFN-α |
STAT1 |
CXCL10/IP10 ↑ |
133 |
Human astrocytes |
IFN-γ/IL-1β |
IFN-γ |
nd |
CXCL11/I-TAC ↑ |
36 |
IFN-β/IL-1β |
IFN-β |
ISGF3 (?) |
CCL5/RANTES ↑ |
32 |
|
Mouse microglia |
IFN-γ |
IFN-γ |
STAT1 |
CXCL9/MIG ↑ |
41 |
Human plasmacytoid DC (MS patient) |
IFN-β/TLR9 ligand |
IFN-β |
nd |
CCL3/MIP1α ↓ |
48 |
CCL4/MIP1β ↓ | |||||
CCL5/RANTES ↓ | |||||
Human T cells (MS patient) |
IFN-β |
IFN-β |
nd |
CCL3/MIP1α ↓ |
47 |
CCL5/RANTES ↓ | |||||
CCR5 ↓ | |||||
Mouse |
MCMV infection |
IFN-I |
nd |
CCL2/MCP1 ↑ |
49 |
CCL3/MIP1α ↑ |
50 |
||||
CCL7/MCP3 ↑ |
51 |
||||
CCL12 ↑ |
|
||||
Mouse liver |
MCMV infection |
IFN-γ |
nd |
CXCL9/MIG ↑ |
49 |
Mouse brain |
LCMV infection |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
55 |
CCL3/MIP1α ↑ | |||||
CCL5/RANTES ↑ | |||||
CXCL10/IP10 ↑ | |||||
Mouse cornea |
HSV-1 |
IFN-α |
nd |
CCL2/MCP1 ↑ |
34 |
Mouse |
Vaccinia virus |
IFN-I, IFN-γ |
nd |
CXCL9/MIG ↑ |
134 |
West Nile virus |
IFN-I |
nd |
CCL2/MCP1 ↑ |
135 |
|
CCL5/RANTES ↑ | |||||
CXCL10/IP10 ↑ | |||||
Influenza virus |
IFN-I |
nd |
CXCL1/KC ↓ |
23 |
|
Streptococcus pneumoniae |
CXCL2/MIP2 ↓ |
||||
Mouse peritoneal cavity |
Listeria monocytogenes |
IFN-I |
nd |
CCL2/MCP1 ↑ |
42 |
nd |
STAT1 (macrophages) |
CCL3/MIP1α ↓ |
26 |
||
STAT1 (DC) |
CCL2/MCP1 ↑ |
||||
CCL5/RANTES ↑ | |||||
STAT1 (T cells) |
CCL2/MCP1 ↑ |
||||
CCL5/RANTES ↑ | |||||
Mouse |
Francisella tularensis |
IFN-γ |
nd |
CCL2/MCP1 ↑ |
52 |
Polymicrobial peritonitis (CASP) |
IFN-I |
nd |
CCL2 ↓ |
78 |
|
Polymicrobial peritonitis (CLP) |
IFN-I |
nd |
CXCL10 ↑ |
53 |
|
Trypanosoma cruzi |
IFN-γ |
nd |
CXCL9/MIG ↑ |
136 |
|
CXCL10/IP10 ↑ | |||||
Paracoccidioides brasiliensis |
IFN-γ |
nd |
CCL5/RANTES ↑ |
137 |
|
CXCL1/KC/GROα ↓ | |||||
CCL3/MIP1α ↓ | |||||
Candida albicans |
IFN-I |
nd |
CCL2/MCP1 ↑ |
71 |
|
CXCL1/KC/GROα ↑ | |||||
Mouse thyroid gland |
IFN-γ transgene (thyroid gland) |
IFN-γ |
nd |
CXCL9/MIG ↑ |
56 |
CXCL10/IP10 ↑ | |||||
CCL4/MIP1β ↑ | |||||
CCL5/RANTES ↑ | |||||
CXCL11/I-TAC ↑ | |||||
Mouse mast cells |
Imiquimod |
IFN-I |
nd |
CCL2/MCP1 ↑ |
59 |
Mouse |
TNF |
IFN-I |
nd |
CXCL9/MIG ↑ |
27 |
CXCL10/IP10 ↑ | |||||
CXCL11/I-TAC ↑ | |||||
Allergic asthma |
IFN-γ |
STAT1 |
CXCL9/MIG ↑ |
58 |
|
CXCL10/IP10 ↑ | |||||
ConA-induced hepatitis |
IFN-γ |
STAT1 |
CXCL5/ENA-78 ↑ |
138 |
|
CXCL9/MIG ↑ | |||||
CXCL10/IP10 ↑ | |||||
CXCL11/I-TAC ↑ | |||||
Mouse (astrocytes) |
EAE |
IFN-γ |
nd |
CXCL10/IP10 ↑ |
57 |
Human (MS patient) | IFN-β | IFN-β | nd | CCL2/MCP1 ↑ |
139 |
CXCL10/IP10 ↑ |
nd, not determined