Table 3.
Growth-inhibitory effect of AGP, SRJ09, and SRJ23 on prostate (PC-3), colon (HCT-116), and breast MDA-231 cancer cells
| GI50, µM |
|||
| Compounds | PC-3* | HCT-116† | MDA-231† |
| AGP | 9.7 ± 1.3 | 4.5 ± 1.8 | 5.9 ± 1.4 |
| SRJ09 | 12.4 ± 1.3 | 3.1 ± 0.7 | 5.0 ± 0.4 |
| SRJ23 | 6.6 ± 0.5 | 4.0 ± 1.2 | 5.8 ± 0.7 |
Ras status was obtained from the Catalog of Somatic Mutations in Cancer, Wellcome Trust Sanger Institute. Values represent mean ± SD of three independent experiments.
*
Wild-type for H-, K-, and N-Ras.
†
Mutant K-Ras (substitution, p.G13D) and wild-type for H- and N-Ras.