Skip to main content
. 2009 Jul 1;5(5):625–635. doi: 10.4161/auto.5.5.8133

Table 1. Loss of T cells in Atg5−/−, Atg5F/F Cre+ and Atg7F/F Cre+ mice.

  Atg5 +/+ Atg5−/− p value Atg5F/F Cre− Atg5F/F Cre+ p value Atg7F/F Cre− Atg7F/F Cre+ p value
Thymus
 160.9 ± 9.9
 66.8 ± 8.0
 p < 0.0001
 165.0 ± 12.2
 108.7 ± 9.1
 p = 0.0004
 155.1 ± 19.8
 89.8 ± 11.6
 p = 0.0104
 
 (n = 41)
 (n = 44)
  
 (n = 25)
 (n = 29)
  
 (n = 8)
 (n = 9)
  
Lymph Nodes
  
  
  
  
  
  
  
  
  
CD4+
 13.6 ± 0.9
 1.3 ± 0.3
 p < 0.0001
 9.1 ± 0.9
 4.3 ± 1.0
 p = 0.0011
 7.5 ± 1.5
 2.3 ± 0.4
 p = 0.0056
 
 (n = 34)
 (n = 37)
  
 (n = 16)
 (n = 20)
  
 (n = 7)
 (n = 7)
  
CD8+
 7.5 ± 0.6
 0.9 ± 0.6
 p < 0.0001
 5.6 ± 0.6
 2.1 ± 0.6
 p = 0.0005
 5.1 ± 1.1
 0.6 ± 0.1
 p = 0.0020
 
 (n = 34)
 (n = 37)
  
 (n = 16)
 (n = 20)
  
 (n = 7)
 (n = 7)
  
Spleen
  
  
  
  
  
  
  
  
  
CD4+
 8.1 ± 0.6
 1.7 ± 0.2
 p < 0.0001
 10.4 ± 4.3
 4.3 ± 0.6
 p < 0.0001
 6.2 ± 0.9
 3.6 ± 0.7
 p = 0.0366
 
 (n = 37)
 (n = 41)
  
 (n = 20)
 (n = 24)
  
 (n = 7)
 (n = 7)
  
CD8+
 4.0 ± 0.3
 2.5 ± 0.4
 p = 0.0031
 6.2 ± 0.6
 3.6 ± 0.4
 p = 0.0012
 4.7 ± 0.8
 1.0 ± 0.3
 p = 0.0012
  (n = 37) (n = 41)   (n = 20) (n = 24)   (n = 7) (n = 7)  

Data are mean ± SEM and represent multiples of 106 cells. The number of mice per group is indicated in parentheses. Chimera mice were analyzed between 6 and 13 weeks post-reconstitution. Atg5F/F Cre mice were analyzed between 6 and 13 weeks of age. Atg7F/F Cre mice were analyzed between 8 and 14 weeks of age.