Table 3.
Neurotransmitter Receptors in Microglia
| Receptor | Source | Expression |
|---|---|---|
| A1 A2A; A2B; A3 | rat/mouse primary | proliferation, survival, cytokine, trophic effect |
| P2X1, P2X4, P2X7 | rat brain sections | Embryonic P2x1, P2X4; Adult P2X4; P2X7 |
| P2X4 | rat spinal cord | Activated microglia/neuropathic pain |
| P2X7 | primary/line/slice | Activated microglia, cytokine release |
| P2Y2; P2Y6; P2Y12; P2Y13 | Mouse primary | Microglia activation, migration, pain |
| GluR1, GluR2, GluR3, GluR4 | primary/cell line | TNFα, cytoskeleton remodeling, chemotaxis |
| mGluR5a | rat primary | Ca2+ transient |
| mGluR2, mGluR4 | rat primary | TNFα, microglia activation |
| mGluR6, mGluR8 | rat primary | reduced neurotoxicity |
| GABAB(1a); b(1b); B(1c) | rat/mouse primary/slice | increased facial nerve axotomy microglia |
| α7 nACh | rat/mouse primary | nicotine triggered Ca2+ transients |
| α1A, α2A, β1, β2 | rat primary | cytokine release |
| Dopamine (D1, D2) | rat/mouse primary/slice | activated outward K+ currents |
| AMPA/KA | primary | only on proliferating microglia |
Source indicates species and type of cell culture