TABLE 2. Summary of Loci Reaching Genome-Wide Significance.
All results reported here include a genomic control correction for individual studies and also for the final meta-analysis51.
| SNP/Risk Allele | Chromosome, Position | Nearby Genes | EAF | Discovery | Follow-up | Joint | 95% CI | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| P | OR | P | OR | P | OR | ||||||
| Loci Previously Reported With P < 5×10−8 | |||||||||||
| rs10490924/T | 10 | 124.2 Mb | ARMS2/HTRA1 | 0.30 | 4×10−353 | 2.71 | 2.8×10−190 | 2.88 | 4×10−540 | 2.76 | [2.72–2.80] |
| rs10737680/A | 1 | 196.7 Mb | CFH | 0.64 | 1×10−283 | 2.40 | 2.7×10−152 | 2.50 | 1×10−434 | 2.43 | [2.39–2.47] |
| rs429608/G | 6 | 31.9 Mb | C2/CFB | 0.86 | 2×10−54 | 1.67 | 2.4×10−37 | 1.89 | 4×10−89 | 1.74 | [1.68–1.79] |
| rs2230199/C | 19 | 6.7 Mb | C3 | 0.20 | 2×10−26 | 1.46 | 3.4×10−17 | 1.37 | 1×10−41 | 1.42 | [1.37–1.47] |
| rs5749482/G | 22 | 33.1 Mb | TIMP3 | 0.74 | 6×10−13 | 1.25 | 9.7×10−17 | 1.45 | 2×10−26 | 1.31 | [1.26–1.36] |
| rs4420638/A | 19 | 45.4 Mb | APOE | 0.83 | 3×10−15 | 1.34 | 4.2×10−7 | 1.25 | 2×10−20 | 1.30 | [1.24–1.36] |
| rs1864163/G | 16 | 57 Mb | CETP | 0.76 | 8×10−13 | 1.25 | 8.7×10−5 | 1.17 | 7×10−16 | 1.22 | [1.17–1.27] |
| rs943080/T | 6 | 43.8 Mb | VEGFA | 0.51 | 4×10−12 | 1.18 | 1.6×10−5 | 1.12 | 9×10−16 | 1.15 | [1.12–1.18] |
| rs13278062/T | 8 | 23.1 Mb | TNFRSF10A | 0.48 | 7×10−10 | 1.17 | 6.4×10−7 | 1.14 | 3×10−15 | 1.15 | [1.12–1.19] |
| rs920915/C | 15 | 58.7 Mb | LIPC | 0.48 | 2×10−9 | 1.14 | 0.004 | 1.10 | 3×10−11 | 1.13 | [1.09–1.17] |
| rs4698775/G | 4 | 110.6 Mb | CFI | 0.31 | 2×10−10 | 1.16 | 0.025 | 1.08 | 7×10−11 | 1.14 | [1.10–1.17] |
| rs3812111/T | 6 | 116.4 Mb | COL10A1 | 0.64 | 7×10−8 | 1.13 | 0.022 | 1.06 | 2×10−8 | 1.10 | [1.07–1.14] |
|
| |||||||||||
| Loci Reaching P < 5×10−8 for the First Time | |||||||||||
| rs13081855/T | 3 | 99.5 Mb | COL8A1/FILIP1L | 0.10 | 4×10−11 | 1.28 | 6.0×10−4 | 1.17 | 4×10−13 | 1.23 | [1.17–1.29] |
| rs3130783/A | 6 | 30.8 Mb | IER3/DDR1 | 0.79 | 1×10−6 | 1.15 | 3.5×10−6 | 1.16 | 2×10−11 | 1.16 | [1.11–1.20] |
| rs8135665/T | 22 | 38.5 Mb | SLC16A8 | 0.21 | 8×10−8 | 1.16 | 5.6×10−5 | 1.13 | 2×10−11 | 1.15 | [1.11–1.19] |
| rs334353/T | 9 | 101.9 Mb | TGFBR1 | 0.73 | 9×10−7 | 1.13 | 6.7×10−6 | 1.13 | 3×10−11 | 1.13 | [1.10–1.17] |
| rs8017304/A | 14 | 68.8 Mb | RAD51B | 0.61 | 9×10−7 | 1.11 | 2.1×10−5 | 1.11 | 9×10−11 | 1.11 | [1.08–1.14] |
| rs6795735/T | 3 | 64.7 Mb | ADAMTS9/MIR548A2 | 0.46 | 9×10−8 | 1.13 | 0.0066 | 1.07 | 5×10−9 | 1.10 | [1.07–1.14] |
| rs9542236/C | 13 | 31.8 Mb | B3GALTL | 0.44 | 2×10−6 | 1.12 | 0.0018 | 1.08 | 2×10−8 | 1.10 | [1.07–1.14] |
See Supplementary Table 5 for a summary of all gene name abbreviations used in this Table and elsewhere in the paper. EAF is the allele frequency of the risk increasing allele.