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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Cancer. 2013 Jan 10;119(8):1528–1536. doi: 10.1002/cncr.27938

Table 3.

Univariate Survival for Clinicopathological Variables (N=25,291)

Variable Time-to Recurrence Disease-Free Survival Overall Survival
HR (95% CI) P-value1 HR (95% CI) P-value1 HR (95% CI) P-value1
Categorical BMI (Overall) 0.0208 0.0069 0.0030
 Normal Reference Reference Reference
 Underweight 1.11 (1.02, 1.21) 0.01692 1.11 (1.03, 1.20) 0.00932 1.12 (1.02, 1.22) 0.01322
 Overweight 1.01 (0.96, 1.06) 0.79922 1.00 (0.96, 1.05) 0.93732 1.03 (0.97, 1.08) 0.32832
 Obese 1.07 (1.01, 1.14) 0.02902 1.07 (1.01, 1.13) 0.01742 1.11 (1.04, 1.18) 0.00142
  Class 1 1.06 (0.99, 1.13) 0.11402 1.06 (1.00, 1.13) 0.06812 1.11 (1.04, 1.19) 0.00242
  Class 2/3 1.11 (1.00, 1.22) 0.05002 1.10 (1.00, 1.20) 0.05032 1.09 (0.98, 1.21) 0.10182
Categorical BMI (Men) 0.0015 <.0001 <.0001
 Normal Reference Reference Reference
 Underweight 1.17 (1.01, 1.35) 0.04012 1.23 (1.08, 1.40) 0.00192 1.29 (1.12, 1.48) 0.00042
 Overweight 0.99 (0.93, 1.06) 0.81712 0.97 (0.91, 1.03) 0.26412 0.98 (0.92, 1.05) 0.52132
 Obese 1.14 (1.05, 1.24) 0.00232 1.11 (1.03, 1.20) 0.00732 1.14 (1.04, 1.24) 0.00332
  Class 1 1.12 (1.02, 1.23) 0.01672 1.09 (1.00, 1.18) 0.05582 1.12 (1.02, 1.23) 0.01702
  Class 2/3 1.21 (1.04, 1.40) 0.01272 1.20 (1.04, 1.37) 0.00962 1.19 (1.02, 1.38) 0.02422
Categorical BMI (Women) 0.4660 0.3969 0.2064
 Normal Reference Reference Reference
 Underweight 1.09 (0.98, 1.21) 0.12762 1.09 (0.98, 1.20) 0.10052 1.08 (0.96, 1.20) 0.20282
 Overweight 1.03 (0.95, 1.11) 0.50882 1.04 (0.96, 1.12) 0.33902 1.07 (0.99, 1.16) 0.08622
 Obese 1.00 (0.92, 1.10) 0.94412 1.03 (0.95, 1.12) 0.43422 1.08 (0.99, 1.19) 0.09552
  Class 1 0.98 (0.89, 1.09) 0.77592 1.03 (0.93, 1.13) 0.60042 1.10 (0.99, 1.22) 0.07672
  Class 2/3 1.04 (0.91, 1.19) 0.57382 1.05 (0.92, 1.19) 0.45782 1.05 (0.91, 1.20) 0.53272
Histological Grade3 <.0001 <.0001 <.0001
 Grade 1/2 Reference Reference Reference
 Grade 3/4 1.40 (1.31, 1.49) 1.37 (1.29, 1.46) 1.54 (1.44, 1.65)
Stage <.0001 <.0001 <.0001
 Stage II Reference Reference Reference
 Stage III 2.76 (2.60, 2.92) 2.34 (2.22, 2.46) 2.43 (2.29, 2.57)
Sex 0.3966 <.0001 <.0001
 Women Reference Reference Reference
 Men 1.02 (0.98, 1.06) 1.09 (1.04, 1.13) 1.10 (1.06, 1.15)
Metastatic Lymph Nodes <.0001 <.0001 <.0001
 0 Reference Reference Reference
 1–3 2.09 (1.97, 2.23) 1.83 (1.73, 1.94) 1.87 (1.76, 1.99)
 >3 4.17 (3.91, 4.46) 3.46 (3.26, 3.66) 3.75 (3.52, 4.00)
Treatment Arm <.0001 <.0001 <.0001
 Control Reference Reference Reference
 Experimental 0.88 (0.84, 0.92) 0.89 (0.85, 0.92) 0.91 (0.87, 0.96)
1

Score test from a Cox Regression model after stratifying by study treatment group

2

Wald chi-square p-value

3

Grade1/2: well/moderate differentiation; Grade 3/4: poor/undifferentiated. Missing data for 9205 patients.