Table 2.
Baseline Characteristics of Patients
| Characteristic | No. (%) |
|
|---|---|---|
| 1 n-3 (n = 143) |
1 Control (n = 129) |
|
| Age, mean (SD), y | 55.5 (17.0) | 52.9 (16.5) |
| Women | 68 (48) | 65 (50) |
| Race/ethnicity White (not Hispanic) |
102 (71) | 94 (73) |
| Black (not Hispanic) | 27 (19) | 18 (14) |
| Hispanic | 7 (5) | 16 (12) |
| Other/NA | 5 (5) | 1 (1) |
| Diabetes | 46 (32) | 42 (33) |
| Medical ICU | 122 (85) | 111 (86) |
| APACHE III score, mean (SD)a | 93.8 (24.9) | 91.8 (29.3) |
| Vasopressor use | 78 (55) | 62 (48) |
| Propofol use | 43 (30) | 30 (23) |
| Baseline propofol infusion rate, median (IQR), mg/h | 30.0 (11.0-80.0) | 26.5 (8.0-107.0) |
| Nonpulmonary organ or system failures (maximum of 4), mean (SD), No. |
1.3 (0.8) | 1.3 (0.9) |
| Arterial pressure, mean (SD), mm Hg | 75.1 (13.2) | 76.7 (15.3) |
| Central venous pressure, mean (SD), mm Hg | 10.7 (4.9) | 11.2 (4.1) |
| Prestudy fluid intake, mean (SD), mL/24 h | 5085 (3543) | 4387 (3063) |
| Albumin, mean (SD), g/dL | 2.3 (0.7) | 2.2 (0.7) |
| Tidal volume, mean (SD), mL/kg | 7.0 (1.6) | 6.8 (1.3) |
| Plateau airway pressure, mean (SD), cm H2O | 23.3 (4.8) | 22.8 (5.5) |
| PEEP, mean (SD), cm H2O | 8.6 (3.5) | 8.7 (3.3) |
| Minute ventilation, mean (SD), L/minb | 11.4 (3.1) | 10.6 (2.9) |
| Respiratory rate, mean (SD), breaths/min | 25.7 (7.2) | 24.7 (7.2) |
| PaO2:FIO2 ratio, mean (SD) | 159.9 (75.6) | 172.5 (84.6) |
| Oxygenation index, mean (SD) | 11.7 (7.4) | 10.5 (7.3) |
| Primary cause of lung injury Pneumonia |
74 (52) | 69 (53) |
| Sepsis | 33 (23) | 27 (21) |
| Aspiration | 17(12) | 23 (18) |
| Trauma | 7 (5) | 2(2) |
| Multiple transfusion | 4 (3) | 1 (1) |
| Other | 8 (6) | 7 (5) |
Abbreviations: APACHE III, Acute Physiology and Chronic Health Evaluation III; F1O2, fraction of inspired oxygen; ICU,intensive care unit; IQR, interquartile range; NA, not available; n-3, omega-3; PaO2, partial pressure of arterial oxy-gen; PEEP, positive end-expiratory pressure.
a
Higher scores indicate a higher severity of illness.
b
The n-3 group had a higher minute ventilation and trend toward greater net fluid administration in the 24-hour preen-rollment period than the control group.