Table 3.
Principal component analysis of functional and structural network metrics.
| Component 1 | Component 2 | Component 3 | Component 4 | |
|---|---|---|---|---|
| Functional CC | 0.863 | 0.369 | − 0.33 | − 0.008 |
| Functional CPL | 0.81 | 0.317 | − 0.486 | − 0.012 |
| Functional lambda | 0.551 | 0.471 | 0.672 | 0.047 |
| Functional gamma | 0.813 | 0.328 | − 0.471 | − 0.013 |
| Functional small worldness | 0.174 | 0.327 | 0.92 | 0.05 |
| Functional modularity (Q) | 0.783 | 0.418 | 0.363 | − 0.051 |
| Structural CC | − 0.44 | 0.415 | − 0.221 | 0.04 |
| Structural CPL | − 0.436 | 0.656 | − 0.051 | − 0.604 |
| Structural lambda | − 0.441 | 0.775 | − 0.121 | 0.329 |
| Structural gamma | − 0.455 | 0.671 | − 0.046 | − 0.571 |
| Structural small worldness | − 0.337 | 0.648 | − 0.122 | 0.593 |
| Structural modularity (Q) | − 0.406 | 0.373 | − 0.029 | 0.314 |
| Total variance explained | 33.90% | 25.50% | 17.40% | 10.50% |
| Relationship with diagnosis | b = −0.30, p = 0.009⁎ | b = − 0.13, p = 0.30 | b = 0.01, p = 0.95 | b = −0.32, p = 0.007⁎ |
| Correlation with age (All) | r = 0.24, p = 0.04 | r = 0.07, p = 0.34 | r = − 0.02, p = 0.87 | r = − 0.06, p = 0.62 |
| Correlation with age (TD) | r = 0.28, p = 0.11 | r = − 0.24, p = 0.16 | r = 0.09, p = 0.60 | r = 0.00, p = 1.0 |
| Correlation with age (ASD) | r = 0.30, p = 0.08 | r = 0.35, p = 0.04 | r = − 0.11, p = 0.53 | r = − 0.09, p = 0.62 |
| Correlation with ADOS social (ASD) | r = − 0.04, p = 0.81 | – | – | r = − 0.36, p = 0.04 |
| Correlation with ADOS comm (ASD) | r = − 0.06, p = 0.73 | – | – | r = −0.46, p = 0.005⁎ |
| Correlation with ADI social (ASD) | r = −0.40, p = 0.01⁎ | – | – | r = − 0.18, p = 0.30 |
| Correlation with ADI comm (ASD) | r = − 0.30, p = 0.08 | – | – | r = − 0.11, p = 0.53 |
Top of table displays weighting (bold indicates significant (p < 0.05) weight) of structural metrics (clustering (CC), characteristic path lenghts (CPL), lambda, gamma, small worldness and modularity (Q)) on each of the four principal components. Bottom of table shows regression coefficients and p values with diagnosis and Pearson correlation values with age (controlling for motion), Autism Diagnostic Interview (ADI) and Autism Diagnostic Observation Scale (ADOS) social and communication subscales with each of the principle components (controlling for age and motion).
⁎
Survives FDR (q < 0.05).