Table 3.
Mecp2-Deficient Mice
|
Male Mice |
|||
| Characteristic | Null Allele | Hypomorphic Allele | Female Mice with Hypomorphic Allelea |
| Age at onset | Appear normal for 5 wk | Appear normal for 6 wk | Appear normal for 6+ wk |
| Head/body size | Small head, body size | ||
| Involuntary movements | Tremors | Tremors | Tremors |
| Seizures | Seizures | ||
| Motor function | Motor deficiencies | Motor deficiencies | |
| Motor control | Hindlimb clasping | Stereotypical forepaw motions | Stereotypical forepaw motions |
| Locomotion | Hypoactivity | Hypoactivity | |
| Respiration | Irregular breathing | ||
| Spinal curvature | Kyphosis | ||
| Life span | Death at 6–10 wk | ||
| Social interactions | Anxiety and abnormal social interactions | ||
a
These female mice have not been thoroughly characterized.