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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2013 Jun 6;137:136–149. doi: 10.1016/j.jsbmb.2013.05.012

Table 2.

Recent Crystal Structures of AKR1C3 available in the Protein Data Bank (PDB)

Inhibitor PDB ID Reference
N-phenylanthranilate (N-PA)
 3-phenoxybenzoic acid 3UWE [76]
 Meclofenamic acid 3R6I [77]
 Mefenamic acid 3R43 [77]
1 4DBU [64]
Arylpropionic acids
  (R)-Flurbiprofen 3R94 [77]
  (R)-Ibuprofen 3R8G [77]
  (R)-Naproxen 3UFY [77]
  (S)-Naproxen 3R58 [77]
Indomethacin analogs
 Indomethacin pH 6.8 3UGR [77]
 Indomethacin pH 7.5 3UG8 [77]
 Zomepirac 3R8H [77]
 Sulindac 3R7M [77]
3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids
6 4FAM [61]
8 4FAL [61]
9 4FA3 [61]
Bifunctional inhibitor
10 4DBS [64]