Table 2.
Recent Crystal Structures of AKR1C3 available in the Protein Data Bank (PDB)
Inhibitor | PDB ID | Reference |
---|---|---|
N-phenylanthranilate (N-PA) | ||
3-phenoxybenzoic acid | 3UWE | [76] |
Meclofenamic acid | 3R6I | [77] |
Mefenamic acid | 3R43 | [77] |
1 | 4DBU | [64] |
Arylpropionic acids | ||
(R)-Flurbiprofen | 3R94 | [77] |
(R)-Ibuprofen | 3R8G | [77] |
(R)-Naproxen | 3UFY | [77] |
(S)-Naproxen | 3R58 | [77] |
Indomethacin analogs | ||
Indomethacin pH 6.8 | 3UGR | [77] |
Indomethacin pH 7.5 | 3UG8 | [77] |
Zomepirac | 3R8H | [77] |
Sulindac | 3R7M | [77] |
3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids | ||
6 | 4FAM | [61] |
8 | 4FAL | [61] |
9 | 4FA3 | [61] |
Bifunctional inhibitor | ||
10 | 4DBS | [64] |