. Author manuscript; available in PMC: 2013 Oct 23.

Published in final edited form as: Nat Rev Cancer. 2013 Jul 4;13(8):572–583. doi: 10.1038/nrc3557

Table 1.

Candidate Drivers of Cell Transformation

Candidate oncogenes and tumor suppressor genes in one carbon metabolism

Pathway	Genes or Enzymes	Evidence
De Novo Serine Biosynthesis	PHGDH, PSAT, PSPH, SHMT1	Genetic Aberrations, Functional Data
Glycine Cleavage	GLDC, GCAT	Overexpression, Functional Data
Polyamine Synthesis	AMD1, EIF5A, SRM, DHPS	Underexpression, Functional Data
Methylation Metabolism	IDH1, EZH2, SET9, DNMT1, ARID1A, JARID1C, UTX, SETD2	Genetic Aberrations, Functional Data