Table 3.
Drug targets in one carbon metabolism
| Enzymes | Compounds | Status |
|---|---|---|
| Methotetrahydrofolate Reductase | Methotrexate, Pemetrexed | Approved for multiple cancers |
| Thymidylate Synthase | 5-Fluorouracil (5-FU) | Approved for multiple cancers most notably Colorectal Cancer |
| Ribonucleotide Reductase | Gemcitabine | Approved for multiple cancers most notably Pancreatic Cancer |
| Polyamine Inhibitors | Various | Clinical trials ongoing |
| DNA Methyltransferase Inihibitors | Azanucleosides | Approved for Myeloid Leukemias |
| Histone Methyltransferase Inhibitors | Various (SAM-analogs) | Clinical trials ongoing |
| Histone Demethylase Inhibitors | Various | Preclinical studies |
| Ornithine Decarboxylase | 2-difluoromethyl ornithine (DMFO) | Preclinical studies |
| S-adenosyl decarboxylase inhibitors | methylglyoxal bis(guanylhydrazone) (MGBG), 4-amidinoindydrazone-1-(SAM486A) | Preclinical studies |