Table 1.
The MHC class II prediction tools available at IEDB. A user may choose from one of the seven prediction methods provided. The consensus method is used as the default method and is composed of three of the most successful individual prediction methods.
| Methods | Prediction based on | Reference |
|---|---|---|
| Consensus | Combination of NN-align, SMM-align and CombLib | Wang et al., 2010 [38] |
| NetMHCIIpan | Artificial neural network | Nielsen et al., 2010 [31] |
| NN-align | Artificial neural network | Nielsen and Lund, 2009 [35] |
| SMM-align | Stabilization matrix alignment | Nielsen et al., 2007 [11] |
| Combinatorial library | Position scanning combinatorial libraries | Wang et al., 2008 [33] Wang et al., 2010 [38] |
| Sturniolo | Scoring matrix based | Sturniolo et al., 1999 [39] |
| ARB | Average relative binding | Bui et al., 2005 [30] |