Fig. 4.
Nfĸb1−/− mice were more sensitive, and Nfĸb2−/− mice more resistant, to LPS-induced small intestinal injury. (A) Villus heights of duodenal villi 1.5 hours after 0.125 mg/kg or 10 mg/kg PE-LPS in WT, Nfκb1−/− and Nfκb2−/− mice (comparisons between genotypes within same dosage groups only). (B,C) Quantification of apoptotic and shedding IECs in duodenal sections labeled for active caspase-3 in WT, Nfĸb1−/− and Nfĸb2−/− mice 1.5 hours after 10 mg/kg PE-LPS (B) and after 0.125 mg/kg PE-LPS (C). n=12–14 (male and female equally represented); *P<0.05, comparisons by Kruskal-Wallis.