. 2008 Dec 29;13(3):454–471. doi: 10.1111/j.1582-4934.2008.00639.x

3.

Changes in blood level of EMP in patients with cardiovascular and other diseases

Disease/condition	EMP changes and phenotypes			Methods	Main finding(s)
Acute Coronary syndrome	↑	CD146⁺, CD31 ⁺	SPC	Elevated EMP levels with a pro-coagulant activity	[55]
↑		CD31⁺			FCM	EMP levels correlated with high-risk lesions	[61]
Stroke	↑	CD105⁺, CD144⁺	FCM	Link between EMP, severity lesions and clinical outcome	[62]
Hypertension	↑	CD31⁺/CD42⁻	FCM	EMP levels correlated with both SBP and DPB	[63]
Pulmonaryhypertension	↑	CD31 ⁺/CD41⁻, CD144	FCM	Levels of EMP predict haemodynamic severity of pulmonary hypertension	[64]
Type 2 diabetes	↑	CD144⁺	FCM	EMP levels correlated with coronary artery disease	[65]
Type 1 diabetes	↑	CD51⁺	FCM	EMP levels correlated with HbA1c	[66]
End-stage renal disease	↑	CD144⁺, CD31⁺/CD41⁻	FCM	High levels of EMP correlated with impaired vascular function	[67]
Antiphospholipidsyndrome	↑	CD51⁺	FCM	EMP correlated with Lupus anticoagulant	[68]
Obesity	↑	CD31⁺/CD42⁻,	FCM	High levels of EMP correlated with altered FMD	[69]
Post-prandial hypertriglyceridemia	↑	CD31⁺/CD42⁻	FCM	EMP correlated with high fat meal	[70]
TTP	↑	CD31⁺, CD51⁺, CD54+, CD62E⁺, CD105⁺, CD106+	FCM	Elevated EMP correlated with endothelial activation	[71]
Paroxysmal nocturnal haemoglo-binuria	↑	CD105⁺, CD144⁺	FCM	Elevated EMP reflected the inflammatorystatus of endothelial cells	[72]
Pulmonary or venous embolism	↑	CD62E⁺, CD31⁺/CD42⁻	FCM		[73]
Sickle cell disease	↑	CD144⁺	FCM	EMP levels correlated with crisis	[53]

Abbreviations: TTP, thrombotic thrombocytopenic purpura, SPC, solid phase capture, SBP, systolic blood pressure, DPB, diastolic blood pressure, FMD, flow mediated dilation.