. Author manuscript; available in PMC: 2014 May 1.

Published in final edited form as: Nat Immunol. 2013 Oct 6;14(11):10.1038/ni.2731. doi: 10.1038/ni.2731

Table 1.

Transcription factors differentiate iNKT cells into NKT1, NKT2 and NKT17 lineages

	PLZF	T-bet	ROR-γt	GATA-3	IRF-4	major cytokine	surface markers	conventional classification
NKT2	high	−	−	+	+	IL-4	CD4⁺CD27⁺CD122⁻	stage 1 and 2
NKT17	intermediate	−	+	+	+	IL-17	CD4⁻CD27⁻CD122⁻	stage 2
NKT1	low	+	−	+/−	−	IFN-γ	CD4^+/−CD27⁺CD122⁺	stage 3