. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: JAMA Neurol. 2013 Nov 1;70(11):10.1001/jamaneurol.2013.3961. doi: 10.1001/jamaneurol.2013.3961

Table 3.

Association of pathologic measure with annual rate of change in different cognitive domains^a

	TDP-43 Pathology			Tangle Density			Amyloid Plaques			Hippocampal Sclerosis
	Estimate	SE	p	Estimate	SE	p	Estimate	SE	p	Estimate	SE	p
Episodic memory	−0.010	0.002	<0.001	−0.006	0.002	0.001	−0.003	0.004	0.459	−0.018	0.040	0.655
Semantic memory	−0.003	0.002	0.143	−0.006	0.002	<0.001	−0.005	0.004	0.177	−0.082	0.036	0.024
Working memory	−0.004	0.002	0.021	−0.005	0.002	<0.001	0.001	0.004	0.782	−0.007	0.032	0.820
Perceptual speed	−0.003	0.002	0.186	−0.007	0.002	<0.001	−0.005	0.004	0.182	−0.057	0.035	0.103
Visuospatial ability	−0.001	0.002	0.761	−0.004	0.001	0.009	−0.003	0.003	0.396	−0.037	0.028	0.195

From 5 separate mixed-effects models adjusted for age at death. Results show the shift in the mean annual rate of cognitive change with each 1-unit of a given pathologic measure.