Table 2.
Biological functions responding to RA treatment and RXRα knockout in wild type mice
| |
Gene number (with RXRα bindings) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Biological functions | RA induced & RXRα KO repressed | RA repressed & RXRα KO induced | ||||||
| Lipid droplet growth |
|
1 |
(0) |
|
|
2 |
(2) |
|
| Transportation of bile aicds for bile excretion |
|
1 |
(0) |
|
|
0 |
|
|
| Dehydrogenation of saturated fatty acids to unsaturated fatty acids |
|
3 |
(2) |
|
|
0 |
|
|
| Biosynthesis of glycerol phosphalipids |
|
4 |
(3) |
|
|
1 |
(1) |
|
| Tryglyceride degration |
|
4 |
(3) |
|
|
0 |
|
|
| Biosynthesis of unsaturated fatty acids responsible for aniti-inflammation |
|
9 |
(7) |
|
|
0 |
|
|
| Elimination of retinoic acids |
|
13 |
(11) |
|
|
0 |
|
|
| Biosynthesis of bile acids |
|
4 |
(4) |
|
|
4 |
(4) |
|
| Biosynthesis of retinoic acids |
|
1 |
(1) |
|
|
2 |
(2) |
|
| Biosynthesis of saturated fatty acids |
|
5 |
(5) |
|
|
10 |
(10) |
|
| Degradation of glycerol phosphalipids |
|
1 |
(1) |
|
|
4 |
(4) |
|
| Degradation of saturated fatty acids |
|
10 |
(10) |
|
|
5 |
(5) |
|
| Elimination of steroid hormones |
|
3 |
(3) |
|
|
5 |
(5) |
|
| Fat digestion and absorption |
|
3 |
(3) |
|
|
7 |
(7) |
|
| Lipid droplet breakdown (fat mobilization) |
|
1 |
(1) |
|
|
1 |
(1) |
|
| Recycle of bile acids via hepatic-intestine |
|
1 |
(1) |
|
|
3 |
(3) |
|
| S1P degradation |
|
1 |
(1) |
|
|
1 |
(1) |
|
| Transportation of bile aicds for kidney excretion |
|
2 |
(2) |
|
|
3 |
(3) |
|
| DHS1P degradation |
|
1 |
(1) |
|
|
0 |
|
|
| Elimination of unsaturated fatty acids (PGE2) responsible for lipolysis inhibition |
|
1 |
(1) |
|
|
0 |
|
|
| phosphatidylcholine to phosphatidylethanolamine |
|
1 |
(1) |
|
|
0 |
|
|
| Sphingolipid biosynthesis |
|
1 |
(1) |
|
|
0 |
|
|
| SPH (SM) degradation |
|
0 |
|
|
|
1 |
(0) |
|
| Biosynthesis of cholesterol |
|
0 |
|
|
|
10 |
(10) |
|
| Biosynthesis of steroid hormone |
|
0 |
|
|
|
1 |
(1) |
|
| Biosynthesis of tryglycerides |
|
0 |
|
|
|
1 |
(1) |
|
| Biosynthesis of unsaturated fatty acids responsible for pro-inflammation |
|
0 |
|
|
|
1 |
(1) |
|
| Breakdown of phosphalipid to form unsaturated fatty acids |
|
0 |
|
|
|
1 |
(1) |
|
| Elimination of cholesterol (from cyculation back to liver for catabolism) |
|
0 |
|
|
|
1 |
(1) |
|
| Elimination of cholesterol via steoid hormone pathway |
|
0 |
|
|
|
1 |
(1) |
|
| Phosphatidylethanolamine to phosphatidylcholine | 0 | 1 | (1) | |||||