. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: J Stroke Cerebrovasc Dis. 2013 Apr 17;22(8):10.1016/j.jstrokecerebrovasdis.2013.03.013. doi: 10.1016/j.jstrokecerebrovasdis.2013.03.013

Table 3.

Main effect of APOE genotype on cognitive decline and moderating effect of APOE genotype on the association between midlife vascular risk factors and later cognitive decline

	APOE ɛ4	HTN	CVD	DM	SMK
WMS LM delayed recall
β ± SE	-0.17 ± 0.07^*	-0.03 ± 0.06	-0.06 ± 0.13	-0.13 ± 0.12	-0.04 ± 0.07
Interaction with APOE	n/a	NS	NS	NS	NS
WMS LM savings
β ± SE	0.00 ± 0.07	0.02 ± 0.06	0.21 ± 0.13	-0.13 ± 0.13	-0.01 ± 0.08
Interaction with APOE	n/a	NS	NS	0.083	NS
WMS VR delayed recall
β ± SE	-0.10 ± 0.07	-0.02 ± 0.06	-0.08 ± 0.12	-0.23 ± 0.12	-0.17 ± 0.07^*
Interaction with APOE	n/a	NS	NS	NS	NS
WMS VR savings
β ± SE	-0.03 ± 0.07	0.05 ± 0.06	0.11 ± 0.13	-0.21 ± 0.13	-0.02 ± 0.08
Interaction with APOE	n/a	NS	NS	NS	NS
WAIS Similarities
β ± SE	-0.01 ± 0.07	0.11 ± 0.06	-0.03 ± 0.13	0.05 ± 0.12	-0.09 ± 0.07
Interaction with APOE	n/a	NS	NS	NS	NS
Trail Making Part A
β ± SE	0.03 ± 0.06	-0.19 ± 0.06^**	-0.35 ± 0.13^**	-0.10 ± 0.12	0.02 ± 0.08
Interaction with APOE	n/a	NS	NS	0.022	NS
Trail Making Test B-A
β ± SE	-0.08 ± 0.07	-0.17 ± 0.06^**	-0.10 ± 0.13	0.13 ± 0.13	0.01 ± 0.08
Interaction with APOE	n/a	NS	NS	NS	NS
Hooper Visual Organization Test
β ± SE	-0.04 ± 0.07	-0.15 ± 0.06^*	-0.20 ± 0.13	0.02 ± 0.13	0.09 ± 0.08
Interaction with APOE	n/a	NS	NS	0.048	NS
Boston Naming Test
β ± SE	0.02 ± 0.07	-0.06 ± 0.06	-0.26 ± 0.12^*	-0.25 ± 0.12^*	0.07 ± 0.07
Interaction with APOE	n/a	0.029	0.032	NS	NS

Abbreviations: HTN = hypertension; CVD = cardiovascular disease; DM = diabetes mellitus; SMK = smoking; n/a = not applicable; NS = not statistically significant (i.e., p > 0.10).

p-value for interaction with APOE genotype listed if p < 0.10

0.01 < p < 0.05

^**

0.001 < p < 0.01