Table 2.
Amount of neutrophils (normalized) at different time points post-ischemia listed according to duration of occlusion (tMCAO and pMCAO)
|
Occlusion time |
Amount of neutrophils (survival time) |
Strain |
n |
Marker |
Reference |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 hours | 6 hours | 12 hours | 18 hours | 1 day | 2 days | 3 days | 4 days | 5 days | 7 days | |||||
| 30 minutes |
|
|
|
|
- |
++ |
|
+++ |
|
+++ |
C57Bl/6 |
4 |
Anti-neutro |
[31] |
| 30 minutes |
|
|
|
|
- |
+ |
|
+++ |
|
+ |
C57Bl/6 |
4 |
Anti-neutro |
[32] |
| 60 minutes |
+ |
|
|
|
+ |
++ |
+++ |
|
|
|
C57Bl/6 |
6 |
NIMP-R14 |
[25] |
| 60 minutes |
- |
|
|
|
++ |
|
+++ |
|
|
|
C57Bl/6 |
5 |
PMN |
[33] |
| 60 minutes |
|
|
|
- |
+ |
++ |
+++ |
++ |
|
|
C57Bl/6 J |
7 |
Lγ-6G |
[34] |
| 60 minutes |
|
|
|
|
|
+++ |
++ |
|
+ |
- |
Wistar |
4 |
MPO |
[35] |
| 60 minutes |
|
- |
++ |
|
++ |
|
+++ |
|
|
- |
Wistar |
6 |
MPO |
[36] |
| 120 minutes |
|
|
++ |
|
+++ |
|
+ |
|
|
|
Wistar |
8 |
MPO |
[37] |
| 120 minutes |
|
|
|
|
+++ |
|
|
- |
|
- |
Sprague–Dawley |
5 |
H&E |
[38] |
| 120 minutesΔ |
|
+ |
++ |
|
+++ |
+++ |
+ |
- |
|
- |
Wistar |
4 |
H&E |
[28] |
| pMCAOΔ |
|
|
- |
|
+ |
+ |
+++ |
+ |
|
- |
Wistar |
6 |
H&E |
[26] |
| pMCAOΔ | - | - | + | +++ | ++ | - | - | Wistar | 5 | H&E | [28] | |||
Crosses represent the following amount of cells presented as percentage of the highest cell number: +, 25 to 49%; ++, 50 to 94%; +++, 95 to 100%; -, <25%. ΔWeighted average. H&E, hematoxylin and eosin; MPO, myeloperoxidase; n, number of animals included; neutro, neutrophil granulocyte; pMCAO, permanent middle cerebral artery occlusion; PMN, polymorphonuclear; tMCAO, transient middle cerebral artery occlusion.