Table 3.
Evaluation of clinical signs and histological EAE in WT, IgHMOG-mem/JHT, and IgHMOG-ki mice
| Ag and mice | Incidence | Onset | Mean maximal clinical score | Mean number of foci (±SEM)a | ||
| Meninges | Parenchyma | Total | ||||
| MOG p35–55 | ||||||
| WT | 15/15 | 11.5 (±0.4) | 3.6 (±0.3) | 238 (±53) | 203 (±39) | 441 (±92) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±1.1) | 3.7 (±0.3) | 117 (±23) | 117 (±24) | 234 (±47) |
| IgHMOG-ki | 15/15 | 11.6 (±1.2) | 3.8 (±0.2) | 118 (±28) | 138 (±23) | 256 (±51) |
| rmMOG | ||||||
| WT | 15/15 | 11.3 (±0.6) | 3.9 (±0.2) | 160 (±33) | 199 (±41) | 339 (±74) |
| IgHMOG-mem/JHT | 18/18 | 11.4 (±0.2) | 3.9 (±0.2) | 189 (±18) | 199 (±12) | 388 (±30) |
| IgHMOG-ki | 15/15 | 11.8 (±0.8) | 3.8 (±0.3) | 137 (±16) | 145 (±24) | 282 (±30) |
| rhMOG | ||||||
| WT | 18/18 | 11.8 (±0.5) | 3.7 (±0.2) | 154 (±47) | 150 (±10) | 304 (±57) |
| IgHMOG-mem/JHT | 18/18 | 11.8 (±0.7) | 3.0 (±0.2) | 118 (±28) | 139 (±23) | 257 (±51) |
| IgHMOG-ki | 17/18 | 10.4 (±0.4) | 4.2 (±0.3) | 146 (±25) | 139 (±18) | 285 (±43) |
Onset indicates mean day of disease onset (paralytic EAE) ± SEM. Clinical score shows mean maximal score of paralytic EAE of diseased mice ± SEM. Composite data from three independent experiments with five to six mice per group are indicated.
a
The infiltration in the brain and spinal cord is quantified as averaged number of meningeal and parenchymal inflammatory foci (>10 clustered inflammatory cells) per CNS tissue section (five mice/group).