Table 1.
18 histopathologic features were categorized as absent (0), present (1+), or abundant (2+) in 171 TCGA GBMs. TILs are associated with specific histopathologic features in GBM.
| Histopathologic Feature | Mantel-Haenzel chi-square p-value |
Spearman correlation |
|---|---|---|
| Inflammation | <0.001 | 0.93 |
| Pseudopalisading necrosis | 0.01 | −0.19 |
| Zonal necrosis | 0.04 | 0.16 |
| Neutrophils | 0.09 | 0.13 |
| Macrophages | <0.001 | 0.32 |
| Microvascular hyperplasia | 0.59 | −0.04 |
| Endothelial hyperplasia | 0.05 | −0.15 |
| Epithelial metaplasia | 0.04 | 0.16 |
| Gemistocytes | 0.01 | 0.22 |
| Giant cells | 0.02 | 0.18 |
| Oligodendroglial cells | 0.01 | −0.19 |
| Sarcomatous metaplasia | <0.01 | 0.22 |
| Small cells | <0.01 | −0.24 |
| Mineralization | 0.68 | 0.03 |
| Satellitosis | 0.20 | −0.10 |
| White matter invasion | 0.09 | −0.13 |
| Cortex invasion | 0.71 | −0.03 |
Mantel-Haenzel chi-square test and Spearman correlation were used to examine associations between lymphocytes (0, 1+, 2+) and other histopathologic features (0, 1+, 2+)
Mantel-Haenzel exact chi-square test was used when 25% of the cells had <5 observations
Effective Sample Size 171