Table 4. Thresholds, Sensitivity and Specificity for Differentiation of Healthy Controls, MCI due to AD, and AD Dementia, for Various Parametersa.
parameter | groups | threshold | sensitivity | specificity |
---|---|---|---|---|
ϕAβ-42 | HC vs Patients | 16.33 pg/mL | 0.91 | 0.88 |
MCI vs ADD | 17.65 pg/mL | 0.69 | 0.68 | |
ϕtau | HC vs Patients | 23.89 pg/mL | 0.97 | 0.91 |
MCI vs ADD | 38.18 pg/mL | 0.78 | 0.82 | |
ϕAβ-42 × ϕTau | HC vs Patients | 455.49 (pg/mL)2 | 0.96 | 0.97 |
MCI vs AD | 642.58 (pg/mL)2 | 0.80 | 0.82 |
HC, healthy controls; MCI, mild cognitive impairment due to Alzheimer’s disease; ADD, Alzheimer’s disease dementia, including those with very mild to severe (CDR = 0.5–3) dementia. ADD and MCI are combined to form Patients.